Development of a Sequential Tetrahydropyran and Tertiary Butyl Deprotection: High-Throughput Experimentation, Mechanistic Analysis, and DOE Optimization
Author:
Affiliation:
1. Department of Process Research, Merck & Co., Inc., Rahway, New Jersey 07065, U.S.A.
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Physical and Theoretical Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/op8002739
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3. The preparation of2will be the focus of a future publication.
4. Synthesis of 2,2-dialkyl-1-aminocyclopropanecarboxylic acids from .alpha.-chloro ketimines
5. A General and Efficient 2-Amination of Pyridines and Quinolines
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