Development of a Manufacturing Process toward the Convergent Synthesis of the COVID-19 Antiviral Ensitrelvir-Reference-Cited by-同舟云学术

Development of a Manufacturing Process toward the Convergent Synthesis of the COVID-19 Antiviral Ensitrelvir

Published:2023-04-07 Issue:4 Volume:9 Page:836-843
ISSN:2374-7943
Container-title:ACS Central Science
language:en
Short-container-title:ACS Cent. Sci.

Author:

Kawajiri Takahiro¹^ORCID,Kijima Akihito¹,Iimuro Atsuhiro²,Ohashi Eisaku¹,Yamakawa Katsuya¹,Agura Kazushi¹,Masuda Kengo²,Kouki Kensuke²,Kasamatsu Koji²,Yanagisawa Shuichi¹,Nakashima Sho¹,Shibahara Setsuya¹,Toyota Takashi¹,Higuchi Takafumi¹,Suto Takahiro²^ORCID,Oohara Tadashi¹,Maki Toshikatsu¹,Sahara Naoto¹,Fukui Nobuaki¹^ORCID,Wakamori Hisayuki¹,Ikemoto Hidaka¹,Murakami Hiroaki¹,Ando Hiroyasu¹,Hosoya Masahiro¹^ORCID,Sato Mizuki¹,Suzuki Yusuke¹,Nakagawa Yuta¹,Unoh Yuto²,Hirano Yoichi¹,Nagasawa Yoshitomo¹,Goda Satoshi¹,Ohara Takafumi¹,Tsuritani Takayuki¹

Affiliation:

1. API R&D Laboratory, Research Division, Shionogi & Co., Ltd., 1-3, Kuise Terajima 2-Chome, Amagasaki, Hyogo 660-0813, Japan

2. Laboratory for Medicinal Chemistry Research, Research Division, Shionogi & Co., Ltd., 1-1, Futaba-cho 3-Chome, Toyonaka, Osaka 561-0825, Japan

Publisher

American Chemical Society (ACS)

Subject

General Chemical Engineering,General Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acscentsci.2c01203

Reference39 articles.

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2. SARS-CoV-2 infection is effectively treated and prevented by EIDD-2801

3. Engineered Ribosyl-1-Kinase Enables Concise Synthesis of Molnupiravir, an Antiviral for COVID-19

4. Development of a Robust Manufacturing Route for Molnupiravir, an Antiviral for the Treatment of COVID-19

5. An oral SARS-CoV-2 M pro inhibitor clinical candidate for the treatment of COVID-19

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