Native Mass Spectrometry Can Effectively Predict PROTAC Efficacy
Author:
Affiliation:
1. Research Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), Campus-Vienna-Biocenter 1, 1030 Vienna, Austria
2. Discovery Research, Boehringer Ingelheim Regional Center Vienna GmbH & Co KG, 1120 Vienna, Austria
Funder
Austrian Science Fund
Publisher
American Chemical Society (ACS)
Subject
General Chemical Engineering,General Chemistry
Link
http://pubs.acs.org/doi/pdf/10.1021/acscentsci.0c00049
Reference32 articles.
1. Chemical approaches to targeted protein degradation through modulation of the ubiquitin–proteasome pathway
2. Small molecule PROTACs: an emerging technology for targeted therapy in drug discovery
3. Degradation of proteins by PROTACs and other strategies
4. Targeted protein degradation: elements of PROTAC design
5. Catalytic in vivo protein knockdown by small-molecule PROTACs
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