Precisely Structured Nitric-Oxide-Releasing Copolymer Brush Defeats Broad-Spectrum Catheter-Associated Biofilm Infections In Vivo

Author:

Hou Zheng12,Wu Yang12,Xu Chen12,Reghu Sheethal12ORCID,Shang Zifang3ORCID,Chen Jingjie3,Pranantyo Dicky4,Marimuth Kalisvar567,De Partha Pratim5,Ng Oon Tek857,Pethe Kevin8ORCID,Kang En-Tang4ORCID,Li Peng3ORCID,Chan-Park Mary B.1298ORCID

Affiliation:

1. School of Chemical and Biomedical Engineering, Nanyang Technological University (NTU), 62 Nanyang Drive, Singapore 637459

2. Centre for Antimicrobial Bioengineering, NTU, 62 Nanyang Drive, Singapore 637459

3. Frontiers Science Center for Flexible Electronics (FSCFE), Xi’an Institute of Flexible Electronics (IFE) & Xi’an Institute of Biomedical Materials and Engineering (IBME), Northwestern Polytechnical University (NPU), 1 Dongxiang Road Changan District, Xi’an 710072, China

4. Department of Chemical & Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Kent Ridge, Singapore 117585

5. Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore 308433

6. Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Road, Singapore 119228

7. National Centre for Infectious Diseases, 16 Jalan Tan Tock Seng, Singapore 308442

8. Lee Kong Chian School of Medicine, Nanyang Technological University, 59 Nanyang Drive, Singapore 636921

9. School of Physical and Mathematical Sciences, 21 Nanyang Link, Singapore 637371

Funder

Singapore Ministry of Health Industry Alignment Fund

National Key R&D Program of China

Centre Grant

Clinician Scientist Award

Singapore Ministry of Education Tier 3 grants

Publisher

American Chemical Society (ACS)

Subject

General Chemical Engineering,General Chemistry

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