Use of an Iridium-Catalyzed Redox-Neutral Alcohol-Amine Coupling on Kilogram Scale for the Synthesis of a GlyT1 Inhibitor-Reference-Cited by-同舟云学术

Use of an Iridium-Catalyzed Redox-Neutral Alcohol-Amine Coupling on Kilogram Scale for the Synthesis of a GlyT1 Inhibitor

Published:2011-08-23 Issue:5 Volume:15 Page:1052-1062
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Berliner Martin A.¹,Dubant Stéphane P. A.²,Makowski Teresa¹,Ng Karl¹,Sitter Barbara¹,Wager Carrie¹,Zhang Yinsheng¹

Affiliation:

1. Chemical Research and Development, Pharmaceutical Sciences, Pfizer Global Research and Development, Groton Laboratories, 558 Eastern Point Rd, Groton, Connecticut 06340, United States

2. Chemical Research and Development, Pharmaceutical Sciences, Pfizer Global Research and Development, Sandwich Laboratories, Ramsgate Road, Sandwich, Kent CT13 9NJ, United Kingdom

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/op200174k

Reference29 articles.

1. Biaryl Phosphane Ligands in Palladium-Catalyzed Amination

2. Large-Scale Applications of Transition Metal-Catalyzed Couplings for the Synthesis of Pharmaceuticals

3. Hydrogen Autotransfer in the N-Alkylation of Amines and Related Compounds using Alcohols and Amines as Electrophiles

4. The discovery of a structurally novel class of inhibitors of the type 1 glycine transporter

5. Recent Progress in the Discovery of Non-Sarcosine Based GlyT1 Inhibitors

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