Synthesis of Bridged Bicyclic Amines by Intramolecular Amination of Remote C–H Bonds: Synergistic Activation by Light and Heat-Reference-Cited by-同舟云学术

Synthesis of Bridged Bicyclic Amines by Intramolecular Amination of Remote C–H Bonds: Synergistic Activation by Light and Heat

Published:2020-08-10 Issue:16 Volume:22 Page:6578-6583
ISSN:1523-7060
Container-title:Organic Letters
language:en
Short-container-title:Org. Lett.

Author:

Lux Michaelyn C.¹,Jurczyk Justin²,Lam Yu-hong³^ORCID,Song Zhiguo J.⁴^ORCID,Ma Chao⁵,Roque Jose B.²^ORCID,Ham Jin Su²,Sciammetta Nunzio⁶,Adpressa Donovon⁷,Sarpong Richmond²^ORCID,Yeung Charles S.⁸^ORCID

Affiliation:

1. MRL Postdoctoral Fellow, Discovery Chemistry, Merck & Co., Inc. 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States

2. Department of Chemistry, University of California, Berkeley, California 94720, United States

3. Computational and Structural Chemistry, Merck & Co., Inc., 126 East Lincoln Avenue, Rahway, New Jersey 07065, United States

4. External Discovery Process Chemistry, Department of Process Research & Development, Merck & Co., 126 East Lincoln Avenue, Rahway, New Jersey 07065, United States

5. WuXi Apptec Co., Ltd., 168 Nanhai Road, Tianjin Economic-Technological Development Area, Tianjin 330457, China

6. Discovery Chemistry, Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States

7. Analytical Research & Development, Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States

8. Disruptive Chemistry Fellow, Discovery Chemistry, Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States

Funder

Center for Selective C-H Functionalization, National Science Foundation

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.orglett.0c02345

Reference22 articles.

1. The importance of synthetic chemistry in the pharmaceutical industry

2. What Do Medicinal Chemists Actually Make? A 50-Year Retrospective

3. Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals

4. Lowering Lipophilicity by Adding Carbon: One-Carbon Bridges of Morpholines and Piperazines

5. Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

Cited by 11 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Ligand‐Promoted Catalyzed Reactions;Organic Reaction Mechanisms Series;2024-03-15

2. Remote C–H Amination and Alkylation of Camphor at C8 through Hydrogen-Atom Abstraction;Journal of the American Chemical Society;2024-03-06

3. Synthesis of polysubstituted fused pyrrolidines via [2 + 2]/[2 + 3] cycloaddition of azomethine ylides;Organic Chemistry Frontiers;2024

4. Enantioselective Syntheses of 2-Azabicyclo[2.2.1]heptanes via Brønsted Acid Catalyzed Ring-Opening of meso-Epoxides;Organic Letters;2022-11-22

5. 2-Oxa-5-azabicyclo[2.2.1]heptane as a Platform for Functional Diversity: Synthesis of Backbone-Constrained γ-Amino Acid Analogues;The Journal of Organic Chemistry;2022-07-28