Enabling Asymmetric Synthesis of ABBV-3748, a Corrector Compound for the Treatment of Cystic Fibrosis
Author:
Affiliation:
1. Research & Development, AbbVie, Inc., 1 N Waukegan Rd, North Chicago, Illinois 60064, United States
Funder
AbbVie
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.orglett.2c02729
Reference17 articles.
1. CFTR Modulators: The Changing Face of Cystic Fibrosis in the Era of Precision Medicine
2. Modulators of CFTR. Updates on clinical development and future directions
3. Emerging preclinical modulators developed for F508del-CFTR have the potential to be effective for ORKAMBI resistant processing mutants
4. A Therapy for Most with Cystic Fibrosis
5. Discovery of 4-[(2R,4R)-4-({[1-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropyl]carbonyl}amino)-7-(difluoromethoxy)-3,4-dihydro-2H-chromen-2-yl]benzoic Acid (ABBV/GLPG-2222), a Potent Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Corrector for the Treatment of Cystic Fibrosis
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