Discovery of 4-[(2R,4R)-4-({[1-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropyl]carbonyl}amino)-7-(difluoromethoxy)-3,4-dihydro-2H-chromen-2-yl]benzoic Acid (ABBV/GLPG-2222), a Potent Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Corrector for the Treatment of Cystic Fibrosis-Reference-Cited by-同舟云学术

Discovery of 4-[(2R,4R)-4-({[1-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropyl]carbonyl}amino)-7-(difluoromethoxy)-3,4-dihydro-2H-chromen-2-yl]benzoic Acid (ABBV/GLPG-2222), a Potent Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Corrector for the Treatment of Cystic Fibrosis

Published:2018-01-05 Issue:4 Volume:61 Page:1436-1449
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Wang Xueqing¹^ORCID,Liu Bo¹,Searle Xenia¹,Yeung Clinton¹,Bogdan Andrew¹,Greszler Stephen¹^ORCID,Singh Ashvani¹,Fan Yihong¹,Swensen Andrew M¹,Vortherms Timothy¹,Balut Corina¹,Jia Ying¹,Desino Kelly¹,Gao Wenqing¹,Yong Hong¹,Tse Chris¹,Kym Philip¹

Affiliation:

1. Research and Development, AbbVie Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States

Funder

AbbVie

Galapagos

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.7b01339

Reference27 articles.