Structure-Guided Directed Evolution of a Carbonyl Reductase Enables the Stereoselective Synthesis of (2S,3S)-2,2-Disubstituted-3-hydroxycyclopentanones via Desymmetric Reduction-Reference-Cited by-同舟云学术

Structure-Guided Directed Evolution of a Carbonyl Reductase Enables the Stereoselective Synthesis of (2S,3S)-2,2-Disubstituted-3-hydroxycyclopentanones via Desymmetric Reduction

Published:2020-04-22 Issue:9 Volume:22 Page:3444-3448
ISSN:1523-7060
Container-title:Organic Letters
language:en
Short-container-title:Org. Lett.

Author:

Li Juan¹²,Feng Jinhui¹,Chen Xi¹,Gong Jingyao¹³,Cui Yunfeng¹,Zhang Hongliu¹,Bu Dandan¹,Wu Qiaqing¹,Zhu Dunming¹²^ORCID

Affiliation:

1. National Engineering Laboratory for Industrial Enzymes and Tianjin Engineering Research Center of Biocatalytic Technology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, 32 West Seventh Avenue, Tianjin Airport Economic Area, Tianjin 300308, China

2. University of Chinese Academy of Sciences, No.19(A) Yuquan Road, Shijingshan District, Beijing 100049, China

3. Department of Medicinal Chemistry, School of Pharmacy Southwest Medical University, Luzhou, Sichuan 646000, China

Funder

Ministry of Science and Technology of the People's Republic of China

Tianjin Science and Technology Committee

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.orglett.0c00892