Engineered ketoreductase-catalyzed stereoselective reduction of ethyl 2′-ketopantothenate and its analogues: chemoenzymatic synthesis of <scp>d</scp>-pantothenic acid-Reference-Cited by-同舟云学术

Engineered ketoreductase-catalyzed stereoselective reduction of ethyl 2′-ketopantothenate and its analogues: chemoenzymatic synthesis of d-pantothenic acid

Published:2024 Issue:4 Volume:26 Page:2124-2134
ISSN:1463-9262
Container-title:Green Chemistry
language:en
Short-container-title:Green Chem.

Author:

Hu Pan¹,Wu Xiaofan²³,Zhang Yajiao²³,Liu Minjie²³,Tao Yuan²³,Huang Zedu²³^ORCID,Chen Fener¹²³⁴^ORCID

Affiliation:

1. Key Laboratory of Green Chemical Engineering Process of Ministry of Education, School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, Wuhan, 430205, P. R. China

2. Department of Chemistry, Engineering Center of Catalysis and Synthesis for Chiral Molecules, Fudan University, 220 Handan Road, Shanghai, 200433, P. R. China

3. Shanghai Engineering Research Center of Industrial Asymmetric Catalysis of Chiral Drugs, 220 Handan Road, Shanghai, 200433, P. R. China

4. College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang, 330022, P. R. China

Abstract

An asymmetric sustainable route to d-pantothenic acid was developed, centering on the reduction of ethyl 2′-ketopantothenate to ethyl (R)-pantothenate, enabled by an E. coli strain co-expressing an engineered ketoreductase and glucose dehydrogenase.

Funder

National Basic Research Program of China

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/GC/D3GC04344D

Reference38 articles.

1. One Hundred Years of Vitamins-A Success Story of the Natural Sciences

2. Calcium Pantothenate. Part 1. (R,S)-Pantolactone Technology Improvement at the Tonnage Scale

3. Biosynthesis of pantothenate

4. Microbial production of vitamin B5: current status and prospects

5. Metabolic Engineering of Saccharomyces cerevisiae for Vitamin B5 Production

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