Photochemical Dimerization of Plakinidine B Leads to Potent Inhibition of the E3 Ubiquitin-Protein Ligase CBL-B-Reference-Cited by-同舟云学术

Photochemical Dimerization of Plakinidine B Leads to Potent Inhibition of the E3 Ubiquitin-Protein Ligase CBL-B

Published:2022-12-14 Issue:51 Volume:24 Page:9468-9472
ISSN:1523-7060
Container-title:Organic Letters
language:en
Short-container-title:Org. Lett.

Author:

Khong Quan T.¹,Li Donghao²^ORCID,Wilson Brice A. P.¹^ORCID,Ranguelova Kalina³,Dalilian Masoumeh¹⁴,Smith Emily A.¹⁴,Wamiru Antony¹⁴,Goncharova Ekaterina I.¹⁵,Grkovic Tanja¹⁶^ORCID,Voeller Donna⁷,Lipkowitz Stanley⁷,Schnermann Martin J.²^ORCID,O’Keefe Barry R.¹⁶^ORCID,Du Lin¹^ORCID

Affiliation:

1. Molecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201, United States

2. Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 20850, United States

3. Bruker BioSpin Corp, Billerica, Massachusetts 01821, United States

4. Basic Science Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702-1201, United States

5. Advanced Biomedical Computational Science, Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702-1201, United States

6. Natural Products Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Frederick, Maryland 21701-1201, United States

7. Women’s Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-1578, United States

Funder

National Cancer Institute

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.orglett.2c03922

Reference27 articles.

1. Symmetrizing the unsymmetrical

2. Enzymatic dimerization in the biosynthetic pathway of microbial natural products

3. Molecular Bilateral Symmetry of Natural Products: Prediction of Selectivity of Dimeric Molecules by Density Functional Theory and Semiempirical Calculations