Synthesis of Adagrasib (MRTX849), a Covalent KRASG12C Inhibitor Drug for the Treatment of Cancer
Author:
Affiliation:
1. Chemical Process R&D, Mirati Therapeutics, San Diego, California 92121, United States
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.orglett.2c04266
Reference25 articles.
1. KRAS mutation: from undruggable to druggable in cancer
2. Targeting KRAS Mutant in Non-Small Cell Lung Cancer: Novel Insights Into Therapeutic Strategies
3. Development of a Commercial Manufacturing Process for Sotorasib, a First-in-Class KRASG12C Inhibitor
4. Adagrasib is marketed under the brand name Krazati, see: https://www.krazati.com.
5. Adagrasib in Non–Small-Cell Lung Cancer Harboring a KRASG12C Mutation
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