Adventures in Atropisomerism: Total Synthesis of a Complex Active Pharmaceutical Ingredient with Two Chirality Axes-Reference-Cited by-同舟云学术

Adventures in Atropisomerism: Total Synthesis of a Complex Active Pharmaceutical Ingredient with Two Chirality Axes

Published:2018-06-17 Issue:13 Volume:20 Page:3736-3740
ISSN:1523-7060
Container-title:Organic Letters
language:en
Short-container-title:Org. Lett.

Author:

Beutner Gregory¹^ORCID,Carrasquillo Ronald¹,Geng Peng¹,Hsiao Yi¹,Huang Eric C.¹,Janey Jacob¹,Katipally Kishta¹,Kolotuchin Sergei¹,La Porte Thomas¹,Lee Andrew¹,Lobben Paul¹,Lora-Gonzalez Federico¹,Mack Brendan¹,Mudryk Boguslaw¹,Qiu Yuping¹,Qian Xinhua¹,Ramirez Antonio¹,Razler Thomas M.¹^ORCID,Rosner Thorsten¹,Shi Zhongping¹,Simmons Eric¹^ORCID,Stevens Jason¹,Wang Jianji¹,Wei Carolyn¹,Wisniewski Steven R.¹^ORCID,Zhu Ye¹

Affiliation:

1. Chemical & Synthetic Development, Bristol-Myers Squibb Company, 1 Squibb Drive, New Brunswick, New Jersey 08901, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.acs.org/doi/pdf/10.1021/acs.orglett.8b01218

Reference41 articles.

1. Discovery of N -(3-(5-((3-acrylamido-4-(morpholine-4-carbonyl)phenyl)amino)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-methylphenyl)-4-( tert -butyl)benzamide (CHMFL-BTK-01) as a highly selective irreversible Bruton's tyrosine kinase (BTK) inhibitor

2. Discovery of novel BTK inhibitors with carboxylic acids

3. Structural optimization of diphenylpyrimidine derivatives (DPPYs) as potent Bruton's tyrosine kinase (BTK) inhibitors with improved activity toward B leukemia cell lines