Discovery of N -(3-(5-((3-acrylamido-4-(morpholine-4-carbonyl)phenyl)amino)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-methylphenyl)-4-( tert -butyl)benzamide (CHMFL-BTK-01) as a highly selective irreversible Bruton's tyrosine kinase (BTK) inhibitor-Reference-Cited by-同舟云学术

Discovery of N -(3-(5-((3-acrylamido-4-(morpholine-4-carbonyl)phenyl)amino)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-methylphenyl)-4-( tert -butyl)benzamide (CHMFL-BTK-01) as a highly selective irreversible Bruton's tyrosine kinase (BTK) inhibitor

Published:2017-05 Issue: Volume:131 Page:107-125
ISSN:0223-5234
Container-title:European Journal of Medicinal Chemistry
language:en
Short-container-title:European Journal of Medicinal Chemistry

Author:

Liang Qianmao,Chen Yongfei,Yu Kailin,Chen Cheng,Zhang Shouxiang,Wang Aoli,Wang Wei,Wu Hong,Liu Xiaochuan,Wang Beilei,Wang Li,Hu Zhenquan,Wang Wenchao,Ren Tao,Zhang Shanchun,Liu Qingsong,Yun Cai-Hong,Liu Jing^ORCID

Funder

Youth Foundation of National Natural Science Foundation of China

Top-notch Young Professionals

Chinese Academy of Sciences

National Basic Research Program (973) of China

National Natural Science Foundation of China

Hefei Science Center CAS

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference32 articles.

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3. B-cell antigen receptor stimulation activates the human Bruton's tyrosine kinase, which is deficient in X-linked agammaglobulinemia;de Weers;J. Biol. Chem.,1994

4. Temporal differences in the activation of three classes of non-transmembrane protein tyrosine kinases following B-cell antigen receptor surface engagement;Saouaf;Proc. Natl. Acad. Sci. U. S. A.,1994

5. Defective B cell development and function in Btk-deficient mice;Khan;Immunity,1995

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