Construction of Chiral β-Trifluoromethyl Alcohols Enabled by Catalytic Enantioselective Aldol-Type Reaction of CF3CHN2-Reference-Cited by-同舟云学术

Construction of Chiral β-Trifluoromethyl Alcohols Enabled by Catalytic Enantioselective Aldol-Type Reaction of CF3CHN2

Published:2019-05-24 Issue:11 Volume:21 Page:4280-4283
ISSN:1523-7060
Container-title:Organic Letters
language:en
Short-container-title:Org. Lett.

Author:

Rong Meng-Yu¹,Yang Lijun¹,Nie Jing¹,Zhang Fa-Guang¹^ORCID,Ma Jun-An¹²^ORCID

Affiliation:

1. Department of Chemistry, Tianjin Key Laboratory of Molecular Optoelectronic Sciences, and Tianjin Collaborative Innovation Center of Chemical Science & Engineering, Tianjin University, Tianjin 300072, P. R. of China

2. State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, P. R. of China

Funder

Ministry of Science and Technology of the People's Republic of China

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.orglett.9b01468

Reference54 articles.

1. Asymmetric Construction of Stereogenic Carbon Centers Featuring a Trifluoromethyl Group from Prochiral Trifluoromethylated Substrates

2. Catalytic Asymmetric Synthesis of Enantioenriched Heterocycles Bearing a CCF3Stereogenic Center

3. Core-structure-inspired asymmetric addition reactions: enantioselective synthesis of dihydrobenzoxazinone- and dihydroquinazolinone-based anti-HIV agents

4. Catalytic Asymmetric Synthesis of α‐Trifluoromethylated Carbinols: A Case Study of Tertiary Propargylic Alcohols

5. Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design

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