Synthesis of di/trifluoromethyl cyclopropane-dicarbonitriles <i>via</i> [2+1] annulation of fluoro-based diazoethanes with (alkylidene)malononitriles-Reference-Cited by-同舟云学术

Synthesis of di/trifluoromethyl cyclopropane-dicarbonitriles via [2+1] annulation of fluoro-based diazoethanes with (alkylidene)malononitriles

Published:2023 Issue:78 Volume:59 Page:11664-11667
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Gao Cheng-Feng¹,Chen Yue-Ji¹,Nie Jing¹^ORCID,Zhang Fa-Guang¹^ORCID,Cheung Chi Wai¹^ORCID,Ma Jun-An¹²^ORCID

Affiliation:

1. Department of Chemistry, Tianjin Key Laboratory of Molecular Optoelectronic Sciences, Frontiers Science Center for Synthetic Biology (Ministry of Education), Tianjin University, Tianjin 300072, P. R. China

2. Joint School of National University of Singapore and Tianjin University, International Campus of Tianjin University, Binhai New City, Fuzhou, 350207, P. R. China

Abstract

The [2+1] annulation reaction of di/trifluorodiazoethane with (alkylidene)malononitriles is developed to access stereospecific and densely functionalized difluoromethyl and trifluoromethyl cyclopropane-1,1-dicarbonitriles. Further elaborations afford structurally distinct cyclopropyl variants.

Funder

National Key Research and Development Program of China

National Natural Science Foundation of China

Natural Science Foundation of Tianjin Municipal Science and Technology Commission

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2023/CC/D3CC03897A

Reference53 articles.

1. Arylcyclopropanes: Properties, Synthesis and Use in Medicinal Chemistry

2. The “Cyclopropyl Fragment” is a Versatile Player that Frequently Appears in Preclinical/Clinical Drug Molecules

3. Cyclopropanation Strategies in Recent Total Syntheses

4. Catalytic Enantioselective Ring-Opening Reactions of Cyclopropanes

5. Put a ring on it: application of small aliphatic rings in medicinal chemistry

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