Spirocycles as Rigidified sp3-Rich Scaffolds for a Fragment Collection
Author:
Affiliation:
1. Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, U.K.
Funder
Engineering and Physical Sciences Research Council
Royal Society
AstraZeneca
Medical Research Council
Marie Curie Cancer Care
H2020 European Research Council
Biotechnology and Biological Sciences Research Council
Walters family
Selwyn College
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.orglett.9b01499
Reference38 articles.
1. Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma
2. ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets
3. Fragment-Based Approaches in Drug Discovery and Chemical Biology
4. Fragment library design considerations
5. Design Principles for Fragment Libraries: Maximizing the Value of Learnings from Pharma Fragment-Based Drug Discovery (FBDD) Programs for Use in Academia
Cited by 34 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Ynones in dearomative spirocyclisation processes; a review;Tetrahedron Chem;2024-03
2. A simple and efficient sequential (3+2) annulation toward the construction of a novel contiguous dispiroheterocyclic scaffold;Tetrahedron Letters;2024-02
3. Towards a General Access to 1‐Azaspirocyclic Systems via Photoinduced, Reductive Decarboxylative Radical Cyclizations;Chemistry – A European Journal;2024-01-12
4. Palladium-Catalyzed Aerobic Oxidative Spirocyclization of Alkyl Amides with Maleimides via β-C(sp3)–H Activation;Organic Letters;2023-08-22
5. Identification of 5-HT2 Serotonin Receptor Modulators through the Synthesis of a Diverse, Tropane- and Quinuclidine-alkaloid-Inspired Compound Library;Journal of Medicinal Chemistry;2023-08-11
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3