Mechanistic Insights of Copper Catalyzed Trifluoromethyl Aziridine Opening: Regioselective and Stereospecific Aryl Grignard Addition-Reference-Cited by-同舟云学术

Mechanistic Insights of Copper Catalyzed Trifluoromethyl Aziridine Opening: Regioselective and Stereospecific Aryl Grignard Addition

Published:2023-05-16 Issue: Volume: Page:
ISSN:1523-7060
Container-title:Organic Letters
language:en
Short-container-title:Org. Lett.

Author:

Lee Miseon¹,Sulwey Dennis¹,Rotella Madeline E.²^ORCID,Kim Wan Shin¹,Ju Xuan¹,Jiang Qi³,Kozlowski Marisa C.²^ORCID,Lee Jaehee¹^ORCID

Affiliation:

1. Chemical Development, Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, Ridgefield, Connecticut 06877-0368, United States

2. Department of Chemistry, Roy and Diana Vagelos Laboratories, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, United States

3. Material and Analytical Sciences, Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, Ridgefield, Connecticut 06877-0368, United States

Funder

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.orglett.3c01122

Reference26 articles.

1. The role of fluorine in medicinal chemistry

2. Recent advances in the trifluoromethylation methodology and new CF3-containing drugs

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4. Molybdenum chloride catalysts for Z-selective olefin metathesis reactions

5. Asymmetric catalysis for the construction of quaternary carbon centres: nucleophilic addition on ketones and ketimines

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