Multicomponent Dearomative Difluoroalkylation of Isoquinolines with Difluorinated Silyl Enol Ethers: Divergent Synthesis of <i>gem</i>-Difluorinated Heterocycles-Reference-Cited by-同舟云学术

Multicomponent Dearomative Difluoroalkylation of Isoquinolines with Difluorinated Silyl Enol Ethers: Divergent Synthesis of gem-Difluorinated Heterocycles

Published:2023-07-11 Issue:28 Volume:25 Page:5366-5371
ISSN:1523-7060
Container-title:Organic Letters
language:en
Short-container-title:Org. Lett.

Author:

Mu Miaomiao¹,Liu Saimei¹,He Yuru¹,Xu Jinjing¹,Wu Haijian¹,Du Qiyuan¹,Sun Manman¹^ORCID,Yang Jianguo¹^ORCID,Wang Zhiming¹^ORCID

Affiliation:

1. Advanced Research Institute and School of Pharmaceutical Sciences, Taizhou University, Jiaojiang, Zhejiang 318000, P. R. China

Funder

Natural Science Foundation of Zhejiang Province

"Pioneer" and "Leading Goose" R&D Program of Zhejiang

Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.orglett.3c01946

Reference48 articles.

1. C–H Functionalization of Azines

2. An overview of late-stage functionalization in today’s drug discovery

3. Recent Developments in Transition-Metal-Free Functionalization and Derivatization Reactions of Pyridines

4. Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals

5. The medicinal chemist's toolbox for late stage functionalization of drug-like molecules

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