Synthesis of Bicyclo[1.1.0]butanes from Iodo-Bicyclo[1.1.1]pentanes

Author:

Mandler Michael D.1ORCID,Mignone James1,Jurica Elizabeth A.1ORCID,Palkowitz Maximilian D.2ORCID,Aulakh Darpandeep3,Cauley Anthony N.1ORCID,Farley Christopher A.1ORCID,Zhang Shasha3,Traeger Sarah C.1,Sarjeant Amy3ORCID,Paiva Anthony1,Perez Heidi L.1,Ellsworth Bruce A.1ORCID,Regueiro-Ren Alicia1ORCID

Affiliation:

1. Bristol Myers Squibb, Research & Early Development, P.O. Box 4000, Princeton, New Jersey 08543, United States

2. Bristol Myers Squibb, Research & Early Development, 100 Binney Street, Cambridge, Massachusetts 02142, United States

3. Bristol Myers Squibb, Chemical & Synthetic Development, 1 Squibb Drive, New Brunswick, New Jersey 08901, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Reference60 articles.

1. Bioisosteres of the Phenyl Ring: Recent Strategic Applications in Lead Optimization and Drug Design

2. Application of the Bicyclo[1.1.1]pentane Motif as a Nonclassical Phenyl Ring Bioisostere in the Design of a Potent and Orally Active γ-Secretase Inhibitor

3. bYu, Y.; Fischer, C.; Bogen, S. L.; Childers, M. L.; Llinas, F. X. F.; Ellis, J. M.; Esposite, S.; Hoffman, D. M.; Huang, C.; Kattar, S.; Kim, A. J.; Lampe, J. W.; Machacek, M. R.; McMasters, D. R.; Parker, D. L.; Reutershan, M.; Sciammetta, N.; Shao, P. P.; Sloman, D. L.; Sun, W.; Ujjainwalla, F.; Wu, Z.; Gibeau, C. International Patent, WO 2016089830 A1, 2016.

4. Strain-Release Heteroatom Functionalization: Development, Scope, and Stereospecificity

5. Strain-release amination

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1. Organometallic Bridge Diversification of Bicyclo[1.1.1]pentanes;Chemistry – A European Journal;2024-01-10

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