Toward the Design of Molecular Chameleons: Flexible Shielding of an Amide Bond Enhances Macrocycle Cell Permeability-Reference-Cited by-同舟云学术

Toward the Design of Molecular Chameleons: Flexible Shielding of an Amide Bond Enhances Macrocycle Cell Permeability

Author:

Tyagi Mohit¹,Poongavanam Vasanthanathan¹^ORCID,Lindhagen Marika²,Pettersen Anna²,Sjö Peter³,Schiesser Stefan⁴,Kihlberg Jan¹^ORCID

Affiliation:

1. Department of Chemistry−BMC, Uppsala University, Box 576, SE-751 23 Uppsala, Sweden

2. Early Product Development, Pharmaceutical Sciences, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden

3. Drugs for Neglected Diseases initiative (DNDi), 15 Chemin Louis Dunant, 1202 Geneva, Switzerland

4. Medicinal Chemistry, Respiratory, Inflammation and Autoimmunity, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden

Funder

AstraZeneca

Vetenskapsr?det

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

Reference49 articles.

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