A Synthesis of a Spirocyclic Macrocyclic Protease Inhibitor for the Treatment of Hepatitis C-Reference-Cited by-同舟云学术

A Synthesis of a Spirocyclic Macrocyclic Protease Inhibitor for the Treatment of Hepatitis C

Published:2016-03-07 Issue:6 Volume:18 Page:1394-1397
ISSN:1523-7060
Container-title:Organic Letters
language:en
Short-container-title:Org. Lett.

Author:

Chung Cheol K.¹,Cleator Ed²,Dumas Aaron M.²,Hicks Jacqueline D.¹,Humphrey Guy R.¹,Maligres Peter E.¹,Nolting Andrew F.¹,Rivera Nelo¹,Ruck Rebecca T.¹,Shevlin Michael¹

Affiliation:

1. Department of Process Chemistry, Merck Research Laboratories, Merck & Co., Inc., Rahway, New Jersey 07065, United States

2. Department of Process Chemistry, Merck Sharp and Dohme Ltd., Hertford Road, Hoddesdon EN11 9BU, United Kingdom

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.orglett.6b00331

Reference20 articles.

1. Boceprevir for Untreated Chronic HCV Genotype 1 Infection

2. Telaprevir for Previously Untreated Chronic Hepatitis C Virus Infection

3. Novel therapies for hepatitis C — one pill fits all?

4. Discovery of MK-8831, A Novel Spiro-Proline Macrocycle as a Pan-Genotypic HCV-NS3/4a Protease Inhibitor

5. Discovery of MK-5172, a Macrocyclic Hepatitis C Virus NS3/4a Protease Inhibitor

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