Asymmetric “Clip-Cycle” Synthesis of Pyrrolidines and Spiropyrrolidines
Author:
Affiliation:
1. Department of Chemistry, University of York, Heslington, York, North Yorks, U.K., YO10 5DD
2. Centre for Molecular Informatics, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, U.K., CB2 1EW
Funder
Engineering and Physical Sciences Research Council
Leverhulme Trust
University of York
Isaac Newton Trust
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.orglett.0c03090
Reference62 articles.
1. Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals
2. The utilization of spirocyclic scaffolds in novel drug discovery
3. The use of spirocyclic scaffolds in drug discovery
4. Discovery and Optimization of a Novel Spiropyrrolidine Inhibitor of β-Secretase (BACE1) through Fragment-Based Drug Design
5. A Two-Step Synthesis of 2-Spiropiperidines
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