Discovery and Optimization of a Novel Spiropyrrolidine Inhibitor of β-Secretase (BACE1) through Fragment-Based Drug Design-Reference-Cited by-同舟云学术

Discovery and Optimization of a Novel Spiropyrrolidine Inhibitor of β-Secretase (BACE1) through Fragment-Based Drug Design

Published:2012-05-09 Issue:21 Volume:55 Page:9069-9088
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Efremov Ivan V.¹,Vajdos Felix F.¹,Borzilleri Kris A.¹,Capetta Steven¹,Chen Hou¹,Dorff Peter H.¹,Dutra Jason K.¹,Goldstein Steven W.¹,Mansour Mahmoud¹,McColl Alexander¹,Noell Stephen¹,Oborski Christine E.¹,O’Connell Thomas N.¹,O’Sullivan Theresa J.¹,Pandit Jayvardhan¹,Wang Hong¹,Wei BinQing¹,Withka Jane M.¹

Affiliation:

1. Pfizer Worldwide Research, Groton Laboratories, Eastern Point Road, Groton, Connecticut 06340, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm201715d

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