Chemical Modification of a Dehydratase Enzyme Involved in Bacterial Virulence by an Ammonium Derivative: Evidence of its Active Site Covalent Adduct-Reference-Cited by-同舟云学术

Chemical Modification of a Dehydratase Enzyme Involved in Bacterial Virulence by an Ammonium Derivative: Evidence of its Active Site Covalent Adduct

Published:2015-07-16 Issue:29 Volume:137 Page:9333-9343
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

González-Bello Concepción,Tizón Lorena,Lence Emilio,Otero José M.,van Raaij Mark J.¹,Martinez-Guitian Marta²,Beceiro Alejandro²,Thompson Paul³,Hawkins Alastair R.³

Affiliation:

1. Departamento de Estructura de Macromoléculas, Centro Nacional de Biotecnología (CSIC), Campus Cantoblanco, 28049 Madrid, Spain

2. Servicio de Microbiología-INIBIC, Complejo Hospitalario Universitario A Coruña (CHUAC), 15006 A Coruña, Spain

3. Institute of Cell and Molecular Biosciences, Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, United Kingdom

Funder

Xunta de Galicia

European Regional Development Fund

Ministerio de Ciencia e Innovación

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/jacs.5b04080

Reference79 articles.

1. The future challenges facing the development of new antimicrobial drugs

2. Targeting virulence: a new paradigm for antimicrobial therapy

3. Drugs for bad bugs: confronting the challenges of antibacterial discovery

4. Molecular mechanisms that confer antibacterial drug resistance

5. New (and not so new) antibacterial targets – from where and when will the novel drugs come?

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