Axially Chiral N-Benzyl-N,7-dimethyl-5-phenyl-1,7-naphthyridine-6-carboxamide Derivatives as Tachykinin NK1 Receptor Antagonists: Determination of the Absolute Stereochemical Requirements-Reference-Cited by-同舟云学术

Axially Chiral N-Benzyl-N,7-dimethyl-5-phenyl-1,7-naphthyridine-6-carboxamide Derivatives as Tachykinin NK1 Receptor Antagonists: Determination of the Absolute Stereochemical Requirements

Published:1998-10-01 Issue:22 Volume:41 Page:4232-4239
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Ikeura Yoshinori¹,Ishichi Yuji¹,Tanaka Toshimasa¹,Fujishima Akira¹,Murabayashi Mika¹,Kawada Mitsuru¹,Ishimaru Takenori¹,Kamo Izumi¹,Doi Takayuki¹,Natsugari Hideaki¹

Affiliation:

1. Pharmaceutical Research Division and Technology Development Department, Takeda Chemical Industries, Ltd., 2-17-85, Jusohonmachi, Yodogawa-ku, Osaka 532, Japan, and Discovery Research Division, Takeda Chemical Industries, Ltd., 10 Wadai, Tsukuba-shi, Ibaraki 305, Japan

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm980042m

Reference22 articles.

1. Novel, Potent, and Orally Active Substance P Antagonists: Synthesis and Antagonist Activity of N-Benzylcarboxamide Derivatives of Pyrido[3,4-b]pyridine

2. Potent NK1 Receptor Antagonists: Synthesis and Antagonistic Activity of Various Heterocycles with an N-(3,5-Bis(trifluoromethyl)benzyl)-N-methylcarbamoyl Substituent.

3. Discovery of a potent substance P antagonist: recognition of the key molecular determinant

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