Identification of a More Potent Analogue of the Naturally Occurring Alkaloid Huperzine A. Predictive Molecular Modeling of Its Interaction with AChE-Reference-Cited by-同舟云学术

Identification of a More Potent Analogue of the Naturally Occurring Alkaloid Huperzine A. Predictive Molecular Modeling of Its Interaction with AChE

Published:1996-01-01 Issue:46 Volume:118 Page:11357-11362
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Kozikowski Alan P.¹,Campiani Giuseppe¹,Sun Li-Qiang¹,Wang Shaomeng¹,Saxena Ashima¹,Doctor Bhupendra P.¹

Affiliation:

1. Contribution from the Georgetown University Medical Center, Institute for Cognitive and Computational Sciences, 3970 Reservoir Road NW, Washington, DC 20007-2197, Dipartimento Farmaco Chimico Tecnologico, Siena University, Banchi di Sotto 55, 53100 Siena, Italy, Department of Chemistry, Ohio State University, Columbus, Ohio 43210, and Division of Biochemistry, Walter Reed Army Institute of Research, Washington, DC 20307

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/ja9622822

Reference20 articles.

1. The structures of huperzine A and B, two new alkaloids exhibiting marked anticholinesterase activity

2. A palladium-catalyzed route to huperzine A and its analogs and their anticholinesterase activity

3. Identification of amino acid residues involved in the binding of Huperzine A to cholinesterases

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