Irreversible Inactivation of Trypanothione Reductase by Unsaturated Mannich Bases: A Divinyl Ketone as Key Intermediate-Reference-Cited by-同舟云学术

Irreversible Inactivation of Trypanothione Reductase by Unsaturated Mannich Bases: A Divinyl Ketone as Key Intermediate

Published:2005-10-13 Issue:23 Volume:48 Page:7400-7410
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Lee Brittany¹,Bauer Holger¹,Melchers Johannes¹,Ruppert Thomas¹,Rattray Lauren¹,Yardley Vanessa¹,Davioud-Charvet Elisabeth¹,Krauth-Siegel R. Luise¹

Affiliation:

1. Biochemie-Zentrum der Universität Heidelberg, Im Neuenheimer Feld 504, 69120 Heidelberg, Germany, Zentrum für Molekulare Biologie der Universität Heidelberg, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany, UMR 8525 CNRS-Université Lille II-Institut Pasteur de Lille, Institut de Biologie de Lille, 1 Rue du Professor Calmette, BP447 59021 Lille Cedex, France, and Department of Infections and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, U.K.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm0504860

Reference50 articles.

1. METABOLISM AND FUNCTIONS OF TRYPANOTHIONE IN THE KINETOPLASTIDA

2. Trypanothione: A Novel Bis(glutathionyl)spermidine Cofactor for Glutathione Reductase in Trypanosomatids

3. Purification and characterization of trypanothione reductase from Crithidia fasciculata, a new member of the family of disulfide-containing flavoprotein reductases

4. Charge is the major discriminating factor for glutathione reductase versus trypanothione reductase inhibitors

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