Aziridinyldinitrobenzamides: Synthesis and Structure−Activity Relationships for Activation by E. coli Nitroreductase-Reference-Cited by-同舟云学术

Aziridinyldinitrobenzamides: Synthesis and Structure−Activity Relationships for Activation by E. coli Nitroreductase

Published:2004-05-12 Issue:12 Volume:47 Page:3295-3307
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Helsby Nuala A.¹,Atwell Graham J.¹,Yang Shangjin¹,Palmer Brian D.¹,Anderson Robert F.¹,Pullen Susan M.¹,Ferry Dianne M.¹,Hogg Alison¹,Wilson William R.¹,Denny William A.¹

Affiliation:

1. Auckland Cancer Society Research Centre, School of Medical Sciences, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm0498699

Reference54 articles.

1. Gene directed enzyme/prodrug therapy of cancer: Historical appraisal and future prospectives

2. Physical characterisation of the Escherichia coli B gene encoding nitroreductase and its over-expression in Escherichia coli K12

3. Gene Cloning, Purification, and Characterization of NfsB, a Minor Oxygen-Insensitive Nitroreductase from Escherichia coli, Similar in Biochemical Properties to FRase I, the Major Flavin Reductase in Vibrio fischeri

4. The bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954)—I

5. The structure of Escherichia coli nitroreductase complexed with nicotinic acid: three crystal forms at 1.7 Å, 1.8 Å and 2.4 Å resolution

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