The bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954)—I
Author:
Publisher
Elsevier BV
Subject
Pharmacology,Biochemistry
Reference22 articles.
1. 2,4-Dinitro-5-ethyleneiminobenzamide (CB1954); a potent and selective inhibitor of the growth of the Walker carcinoma 256;Cobb;Chem Pharmacol,1969
2. Cell hybridization study of resistance to alkylating agents;Phillips;Nature,1971
3. CB1954 (2,4-dinitro-5-aziridinyl benzamide) becomes a DNA interstrand crosslinking agent in Walker tumour cells;Roberts;Biochem Biophys Res Commun,1986
4. A new cytotoxic, DNA interstrand crosslinking agent; 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide, is formed from 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954) by a nitroreductase enzyme in Walker carcinoma cells;Knox;Biochem Pharmacol,1988
5. The nitroreductase enzyme in Walker cells that activates 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954) to 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide is a form of NAD(P)H dehydrogenase (quinone) (EC 1.6.99.2);Knox;Biochem Pharmacol,1988
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