Structural Rationalization of a Large Difference in RNA Affinity Despite a Small Difference in Chemistry between Two 2‘-O-Modified Nucleic Acid Analogues-Reference-Cited by-同舟云学术

Structural Rationalization of a Large Difference in RNA Affinity Despite a Small Difference in Chemistry between Two 2‘-O-Modified Nucleic Acid Analogues

Published:2004-11-01 Issue:46 Volume:126 Page:15006-15007
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Pattanayek Rekha¹,Sethaphong Latsavongsakda¹,Pan Chongle¹,Prhavc Marija¹,Prakash Thazha P.¹,Manoharan Muthiah¹,Egli Martin¹

Affiliation:

1. Department of Biochemistry, Vanderbilt University, Nashville, Tennessee 37232, Genome Science and Technology, University of Tennessee - Oak Ridge National Laboratory, Oak Ridge, Tennessee 37830, Department of Medicinal Chemistry, Isis Pharmaceuticals Inc., Carlsbad, California 92008, and Department of Drug Discovery, Alnylam Pharmaceuticals, Cambridge, Massachusetts 02142

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/ja044637k

Reference23 articles.

1. Antisense Research and Application

2. The ups and downs of nucleic acid duplex stability: structure-stability studies on chemically-modified DNA:RNA duplexes

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