β-Substituted Cyclohexanecarboxamide: A Nonpeptidic Framework for the Design of Potent Inhibitors of Cathepsin K-Reference-Cited by-同舟云学术

β-Substituted Cyclohexanecarboxamide: A Nonpeptidic Framework for the Design of Potent Inhibitors of Cathepsin K

Published:2006-01-19 Issue:3 Volume:49 Page:1066-1079
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Crane Sheldon N.¹,Black W. Cameron¹,Palmer James T.¹,Davis Dana E.¹,Setti Eduardo¹,Robichaud Joel¹,Paquet Julie¹,Oballa Renata M.¹,Bayly Christopher I.¹,McKay Daniel J.¹,Somoza John R.¹,Chauret Natalie¹,Seto Carmai¹,Scheigetz John¹,Wesolowski Greg¹,Massé Frederic¹,Desmarais Sylvie¹,Ouellet Marc¹

Affiliation:

1. Merck Frosst Centre for Therapeutic Research, 16711 TransCanada Highway, Kirkland, Quebec, Canada, H9H 3L1, Celera Genomics, 180 Kimball Way, South San Francisco, California 94080, and Merck Research Laboratories, West Point, Pennsylvania 19486

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm051059p

Reference21 articles.

1. Human Cathepsin O2, a Matrix Protein-degrading Cysteine Protease Expressed in Osteoclasts

2. Proteolytic Activity of Human Osteoclast Cathepsin K

3. Expression cloning of an insect diuretic hormone receptor. A member of the calcitonin/secretin receptor family.

4. Lysosomal cysteine proteases: more than scavengers

5. Cathepsin K, but Not Cathepsins B, L, or S, Is Abundantly Expressed in Human Osteoclasts

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