Lead optimization of cathepsin K inhibitors for the treatment of Osteoarthritis-Reference-Cited by-同舟云学术

Lead optimization of cathepsin K inhibitors for the treatment of Osteoarthritis

Published:2022-10 Issue: Volume:74 Page:128927
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Ginnetti Anthony T.,Paone Daniel V.,Nanda Kausik K.,Li Jing,Busuek Marina,Johnson Scott A.,Lu Jun,Soisson Stephen M.,Robinson Ronald,Fisher John,Webber Andrea,Wesolowski Gregg,Ma Bennett,Duong Le,Carroll Steven,Burgey Christopher S.,Stachel Shawn J.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference13 articles.

1. Protective effects of a cathepsin K inhibitor, SB-553484, in the canine partial medial meniscectomy model of osteoarthritis

2. Up regulation of cathepsin K expression in articular chondrocytes in a transgenic mouse model for osteoarthritis

3. Inhibition of cathepsin K reduces cartilage degeneration in the anterior cruciate ligament transection rabbit and murine models of osteoarthritis;Hayami;Bone,2012

4. Identification of a nonbasic, nitrile-containing cathepsin K inhibitor (MK-1256) that is efficacious in a monkey model of osteoporosis;Robichaud;J Med Chem,2008

5. Murine cathepsin F deficiency causes neuronal lipofuscinosis and late-onset neurological disease;Tang;Mol Cell Biol,2006

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1. New Developments in Clinical Trials for Osteoarthritis: Are We Closer to Improving Pain Management and Disease Modification?;European Medical Journal;2024-09-12

2. Genetic insights into serum cathepsins as diagnostic and therapeutic targets in knee and hip osteoarthritis;Scientific Reports;2024-07-30

3. Screening of MMP-13 Inhibitors Using a GelMA-Alginate Interpenetrating Network Hydrogel-Based Model Mimicking Cytokine-Induced Key Features of Osteoarthritis In Vitro;Polymers;2024-06-01

4. Mendelian randomization analysis explores the causal relationship between cathepsins and osteoarthritis;2024-05-31

5. What is new in pharmacological treatment for osteoarthritis?;Best Practice & Research Clinical Rheumatology;2023-06