Discovery, Structure, and Mechanism of the (R, S)-Norcoclaurine Synthase for the Chiral Synthesis of Benzylisoquinoline Alkaloids

Author:

Zhang Libo1,Zhang Shiqing23,Liao Lijing4,Tang Huanying1,Wang Wenli5,Yin Fucheng6,Han Liangliang6,Zhu Kejin1,Liu Yushi1,Xu Dingqiao7,Wang Xiaobing6ORCID,Qin Minjian1,Xiao Yibei4,Sheng Xiang23ORCID,Zhao Yucheng1ORCID

Affiliation:

1. Department of Resources Science of Traditional Chinese Medicines, School of Traditional Chinese Pharmacy, and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China

2. Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China

3. National Center of Technology Innovation for Synthetic Biology and National Engineering Research Center of Industrial Enzymes, Tianjin 300308, China

4. Department of Pharmacology, School of Pharmacy, and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China

5. School of Pharmacy, Nantong University, Nantong 226001, China

6. Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China

7. Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for TCM Compatibility, State Key Laboratory of Research & Development of Characteristic Qin Medicine Resources (Cultivation), Shaanxi Key Laboratory of Chinese Medicine Fundamentals and New Drugs Research, Shaanxi University of Chinese Medicine, Xi’an 712046, China

Funder

Shaanxi University of Chinese Medicine

National Key Research and Development Program of China

Ministry of Education of the People's Republic of China

National Natural Science Foundation of China

Tianjin Synthetic Biotechnology Innovation Capacity Improvement Project

Traditional Chinese Medicine Institute of Anhui Dabie Mountain

Key project at the central government level: The ability establishment of sustainable use for valuable Chinese medicine resources

Publisher

American Chemical Society (ACS)

Subject

Catalysis,General Chemistry

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