Discovery, Structure, and Mechanism of the (R, S)-Norcoclaurine Synthase for the Chiral Synthesis of Benzylisoquinoline Alkaloids

Author:

Zhang Libo1,Zhang Shiqing23,Liao Lijing4,Tang Huanying1,Wang Wenli5,Yin Fucheng6,Han Liangliang6,Zhu Kejin1,Liu Yushi1,Xu Dingqiao7,Wang Xiaobing6ORCID,Qin Minjian1,Xiao Yibei4,Sheng Xiang23ORCID,Zhao Yucheng1ORCID

Affiliation:

1. Department of Resources Science of Traditional Chinese Medicines, School of Traditional Chinese Pharmacy, and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China

2. Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China

3. National Center of Technology Innovation for Synthetic Biology and National Engineering Research Center of Industrial Enzymes, Tianjin 300308, China

4. Department of Pharmacology, School of Pharmacy, and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China

5. School of Pharmacy, Nantong University, Nantong 226001, China

6. Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China

7. Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for TCM Compatibility, State Key Laboratory of Research & Development of Characteristic Qin Medicine Resources (Cultivation), Shaanxi Key Laboratory of Chinese Medicine Fundamentals and New Drugs Research, Shaanxi University of Chinese Medicine, Xi’an 712046, China

Funder

Shaanxi University of Chinese Medicine

National Key Research and Development Program of China

Ministry of Education of the People's Republic of China

National Natural Science Foundation of China

Tianjin Synthetic Biotechnology Innovation Capacity Improvement Project

Traditional Chinese Medicine Institute of Anhui Dabie Mountain

Key project at the central government level: The ability establishment of sustainable use for valuable Chinese medicine resources

Publisher

American Chemical Society (ACS)

Subject

Catalysis,General Chemistry

Cited by 3 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3