The opium poppy genome and morphinan production

Author:

Guo Li123ORCID,Winzer Thilo4,Yang Xiaofei15ORCID,Li Yi4ORCID,Ning Zemin6,He Zhesi4ORCID,Teodor Roxana4ORCID,Lu Ying7ORCID,Bowser Tim A.8,Graham Ian A.4ORCID,Ye Kai1239ORCID

Affiliation:

1. MOE Key Lab for Intelligent Networks and Networks Security, School of Electronics and Information Engineering, Xi’an Jiaotong University, Xi’an, 710049 China.

2. The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, 710061 China.

3. The School of Life Science and Technology, Xi’an Jiaotong University, Xi’an, 710049 China.

4. Centre for Novel Agricultural Products, Department of Biology, University of York, York YO10 5DD, UK.

5. Computer Science Department, School of Electronics and Information Engineering, Xi’an Jiaotong University, Xi’an, 710049 China.

6. The Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.

7. Shanghai Ocean University, Shanghai, 201306 China.

8. Sun Pharmaceutical Industries Australia, Princes Highway, Port Fairy, VIC 3284, Australia.

9. Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, China.

Abstract

Poppy genome reveals evolution of opiates The opium poppy has been a source of painkillers since Neolithic times. Attendant risks of addiction threaten many today. Guo et al. now deliver a draft of the opium poppy genome, which encompasses 2.72 gigabases assembled into 11 chromosomes and predicts more than 50,000 protein-coding genes. A particularly complex gene cluster contains many critical enzymes in the metabolic pathway that generates the alkaloid drugs noscapine and morphinan. Science , this issue p. 343

Funder

Wellcome Trust

Biotechnology and Biological Sciences Research Council

National Science Foundation of China

National key R and D program of China

Thousand Talents Plan” and by Key Construction Program of the National “985” Project

The Garfield Weston Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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