Rigidifying a De Novo Enzyme Increases Activity and Induces a Negative Activation Heat Capacity-Reference-Cited by-同舟云学术

Rigidifying a De Novo Enzyme Increases Activity and Induces a Negative Activation Heat Capacity

Published:2021-09-01 Issue:18 Volume:11 Page:11532-11541
ISSN:2155-5435
Container-title:ACS Catalysis
language:en
Short-container-title:ACS Catal.

Author:

Hindson Sarah A.¹,Bunzel H. Adrian²³,Frank Bettina²⁴,Svistunenko Dimitri A.⁵^ORCID,Williams Christopher³^ORCID,van der Kamp Marc W.²^ORCID,Mulholland Adrian J.³^ORCID,Pudney Christopher R.¹^ORCID,Anderson J. L. Ross²^ORCID

Affiliation:

1. Department of Biology and Biochemistry, Centre for Sustainable Chemical Technology, University of Bath, Bath BA2 7AY, U.K.

2. School of Biochemistry, University of Bristol, Bristol BS8 1TD, U.K.

3. Centre for Computational Chemistry, University of Bristol, Bristol BS8 1TS, U.K.

4. Bristol Centre for Functional Nanomaterials, School of Physics, University of Bristol, Bristol BS8 1TL, U.K.

5. School of Life Sciences, University of Essex, Colchester CO4 3SQ, U.K.

Funder

Engineering and Physical Sciences Research Council

Biotechnology and Biological Sciences Research Council

Publisher

American Chemical Society (ACS)

Subject

Catalysis,General Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acscatal.1c01776

Reference49 articles.

1. Broadening the Scope of Biocatalysis in Sustainable Organic Synthesis

2. Directed evolution drives the next generation of biocatalysts

3. Innovation by Evolution: Bringing New Chemistry to Life (Nobel Lecture)

4. De novo enzymes by computational design

5. Designing better enzymes: Insights from directed evolution

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