Cooperative Conformational Transitions Underpin the Activation Heat Capacity in the Temperature Dependence of Enzyme Catalysis

Author:

Walker Emma J.1ORCID,Hamill Carlin J.1,Crean Rory2,Connolly Michael S.2,Warrender Annmaree K.1,Kraakman Kirsty L.1,Prentice Erica J.1ORCID,Steyn-Ross Alistair3,Steyn-Ross Moira3,Pudney Christopher R.4ORCID,van der Kamp Marc W.5ORCID,Schipper Louis A.1,Mulholland Adrian J.2ORCID,Arcus Vickery L.1ORCID

Affiliation:

1. Te Aka Ma̅tuatua School of Science, University of Waikato, Hamilton 3214, New Zealand

2. Centre for Computational Chemistry, School of Chemistry, University of Bristol, Bristol BS8 1TS, U.K.

3. School of Engineering, University of Waikato, Hamilton 3214, New Zealand

4. Department of Biology and Biochemistry, Centre for Biosensors, Bioelectronics and Biodevices, University of Bath, Bath ST16 2TB, U.K.

5. School of Biochemistry, University of Bristol, University Walk, Bristol BS8 1TD, U.K.

Funder

Engineering and Physical Sciences Research Council

University of Waikato

Marsden Fund

H2020 European Research Council

Biotechnology and Biological Sciences Research Council

Publisher

American Chemical Society (ACS)

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