Are Heme-Dependent Enzymes Always Using a Redox Mechanism? A Theoretical Study of the Kemp Elimination Catalyzed by a Promiscuous Aldoxime Dehydratase-Reference-Cited by-同舟云学术

Are Heme-Dependent Enzymes Always Using a Redox Mechanism? A Theoretical Study of the Kemp Elimination Catalyzed by a Promiscuous Aldoxime Dehydratase

Published:2020-09-03 Issue:19 Volume:10 Page:11110-11119
ISSN:2155-5435
Container-title:ACS Catalysis
language:en
Short-container-title:ACS Catal.

Author:

Martí Sergio¹^ORCID,Tuñón Iñaki²^ORCID,Moliner Vicent¹^ORCID,Bertran Joan³^ORCID

Affiliation:

1. Departament de Química Física i Analítica, Universitat Jaume I, 12071 Castellón, Spain

2. Departament de Química Física, Universitat de València, 46100 Burjassot, Spain

3. Departament de Química, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain

Funder

Generalitat Valenciana

Universitat Jaume I

Ministerio de Ciencia e Innovaci?n

Publisher

American Chemical Society (ACS)

Subject

Catalysis,General Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acscatal.0c02215

Reference45 articles.

1. Kemp elimination catalysts by computational enzyme design

2. Physical organic chemistry of benzisoxazoles. I. Mechanism of the base-catalyzed decomposition of benzisoxazoles

3. Medium Effects in Biologically Related Catalysis

4. Computational strategies for the design of new enzymatic functions

5. Evolutionary Optimization of Computationally Designed Enzymes: Kemp Eliminases of the KE07 Series

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