Mechanism of a Dually Catalyzed Enantioselective Oxa-Pictet–Spengler Reaction and the Development of a Stereodivergent Variant

Author:

Adili Alafate1,Webster John-Paul2,Zhao Chenfei3ORCID,Mallojjala Sharath Chandra2,Romero-Reyes Moises A.1,Ghiviriga Ion4ORCID,Abboud Khalil A.5,Vetticatt Mathew J.2ORCID,Seidel Daniel1ORCID

Affiliation:

1. Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, Florida 32611, United States

2. Department of Chemistry, Binghamton University, Binghamton, New York 13902, United States

3. Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, United States

4. Center for NMR Spectroscopy, Department of Chemistry, University of Florida, Gainesville, Florida 32611, United States

5. Center for X-ray Crystallography, Department of Chemistry, University of Florida, Gainesville, Florida 32611, United States

Funder

Division of Chemistry

NIH Office of the Director

Division of Advanced Cyberinfrastructure

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Subject

Catalysis,General Chemistry

Reference148 articles.

1. The Oxa-Pictet-Spengler Cyclization: Synthesis of Isochromans and Related Pyran-Type Heterocycles

2. Synthesis of Oxacycles Employing the Oxa‐Pictet–Spengler Reaction: Recent Developments and New Prospects

3. Catalytic Enantioselective Approaches to the oxa-Pictet–Spengler Cyclization and Other 3,6-Dihydropyran-Forming Reactions

4. aBuschmann, H.; Michel, R. Verfahren zur Herstellung von Isochromanen. German Patent 614461, 1935.

5. bBuschmann, H.; Michel, R. Verfahren zur Herstellung von Isochromanen, Zusatz. German Patent 617646, 1935.

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