Simplification of Corticosteroids Biosynthetic Pathway by Engineering P450BM3-Reference-Cited by-同舟云学术

Simplification of Corticosteroids Biosynthetic Pathway by Engineering P450BM3

Published:2024-03-04 Issue:6 Volume:14 Page:4117-4129
ISSN:2155-5435
Container-title:ACS Catalysis
language:en
Short-container-title:ACS Catal.

Author:

Chen Qihang¹²,Chao Zikai¹²,Wang Ke¹²,Wang Xinglong¹²,Meng Hao³,Liu Xirong³,Shan Xiaoyu¹²,Zhou Jingwen¹²⁴^ORCID

Affiliation:

1. Science Center for Future Foods, School of Biotechnology, Jiangnan University, Wuxi 214122, China

2. Engineering Research Center of Ministry of Education on Food Synthetic Biotechnology, Jiangnan University, 1800 Lihu Road, Wuxi, Jiangsu 214122, China

3. Hunan Norchem Pharmaceutical Co., Ltd., 20 Mengjiangnv Road, Jinshi, Hunan 415400, China

4. Jiangsu Province Engineering Research Center of Food Synthetic Biotechnology, Jiangnan University, 1800 Lihu Road, Wuxi, Jiangsu 214122, China

Funder

National Key Research and Development Program of China

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acscatal.3c06137

Reference44 articles.

1. Rationally Controlling Selective Steroid Hydroxylation via Scaffold Sampling of a P450 Family

2. Shortening Synthetic Routes to Small Molecule Active Pharmaceutical Ingredients Employing Biocatalytic Methods

3. Changing the Regioselectivity of a P450 from C15 to C11 Hydroxylation of Progesterone

4. Oxidative Diversification of Steroids by Nature-Inspired Scanning Glycine Mutagenesis of P450BM3 (CYP102A1)

5. Total biosynthesis of hydrocortisone from a simple carbon source in yeast

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