Pharmacokinetics of Saquinavir After Intravenous and Oral Dosing of Saquinavir: Hydroxybutenyl-β-Cyclodextrin Formulations
Author:
Affiliation:
1. Eastman Chemical Company, Research Laboratories, P.O. Box 1972, Kingsport, Tennessee 37662, and Department of Pharmacology, East Tennessee State University, Johnson City, Tennessee 37614
Publisher
American Chemical Society (ACS)
Subject
Materials Chemistry,Polymers and Plastics,Biomaterials,Bioengineering
Link
https://pubs.acs.org/doi/pdf/10.1021/bm700827h
Reference28 articles.
1. UNAIDS/WHO AIDS Epidemic Update;www.unaids.org/en/HIV_data/epi2006/default.asp, December 2006.
2. P-Glycoprotein Limits Oral Availability, Brain, and Fetal Penetration of Saquinavir Even with High Doses of Ritonavir
3. Hepatic and Intestinal Contributions to Pharmacokinetic Interaction of Indinavir with Amprenavir, Nelfinavir and Saquinavir in Rats
4. Factors Responsible for the Variability of Saquinavir Absorption: Studies Using an Instrumented Dog Model
5. Differentiation of Gut and Hepatic First Pass Metabolism and Secretion of Saquinavir in Ported Rabbits
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