Reactions of Functionalized Sulfonamides: Application to Lowering the Lipophilicity of Cytosolic Phospholipase A2α Inhibitors-Reference-Cited by-同舟云学术

Reactions of Functionalized Sulfonamides: Application to Lowering the Lipophilicity of Cytosolic Phospholipase A2α Inhibitors

Published:2009-01-29 Issue:4 Volume:52 Page:1156-1171
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Chen Lihren¹,Wang Weiheng¹,Lee Katherine L.¹,Shen Marina W. H.¹,Murphy Elizabeth A.¹,Zhang Wen¹,Xu Xin¹,Tam Steve¹,Nickerson-Nutter Cheryl¹,Goodwin Debra G.¹,Clark James D.¹,McKew John C.¹

Affiliation:

1. Departments of Chemical and Screening Sciences, Inflammation, and Drug Safety and Metabolism, Wyeth Research, 200 CambridgePark Drive, Cambridge, Massachusetts 02140

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm8009876

Reference34 articles.

1. Cytosolic phospholipase A2

2. Processive interfacial catalysis by mammalian 85-kilodalton phospholipase A2 enzymes on product-containing vesicles: Application to the determination of substrate preferences

3. Synthetic Inhibitors of Group IVA and Group VIA Phospholipase A2

4. Inhibition of Group IVA Cytosolic Phospholipase A2 by Novel 2-Oxoamides in Vitro, in Cells, and in Vivo

5. Role of cytosolic phospholipase A2 in allergic response and parturition

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