Discovery of Highly Potent Human Deoxyuridine Triphosphatase Inhibitors Based on the Conformation Restriction Strategy-Reference-Cited by-同舟云学术

Discovery of Highly Potent Human Deoxyuridine Triphosphatase Inhibitors Based on the Conformation Restriction Strategy

Published:2012-05-30 Issue:11 Volume:55 Page:5483-5496
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Miyahara Seiji¹²,Miyakoshi Hitoshi¹³,Yokogawa Tatsushi¹,Chong Khoon Tee¹,Taguchi Junko¹,Muto Toshiharu¹,Endoh Kanji¹,Yano Wakako¹,Wakasa Takeshi¹,Ueno Hiroyuki¹,Takao Yayoi¹,Fujioka Akio,¹,Hashimoto Akihiro¹,Itou Kenjirou¹,Yamamura Keisuke¹,Nomura Makoto¹,Nagasawa Hideko³,Shuto Satoshi²,Fukuoka Masayoshi¹

Affiliation:

1. Tsukuba Research Center, Taiho Pharmaceutical Co. Ltd., Okubo 3, Tsukuba, Ibaraki 300-2611, Japan

2. Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan

3. Laboratory of Pharmaceutical and Medicinal Chemistry, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu 501-1196, Japan

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm300416h

Reference42 articles.

1. 5-Fluorouracil: mechanisms of action and clinical strategies

2. Thymidylate synthase: A target for anticancer drug design

3. Folate-based thymidylate synthase inhibitors as anticancer drugs

4. Thymidylate Synthase Expression and Prognosis in Colorectal Cancer: A Systematic Review and Meta-Analysis

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