Discovery and Optimization of an Azetidine Chemical Series As a Free Fatty Acid Receptor 2 (FFA2) Antagonist: From Hit to Clinic-Reference-Cited by-同舟云学术

Discovery and Optimization of an Azetidine Chemical Series As a Free Fatty Acid Receptor 2 (FFA2) Antagonist: From Hit to Clinic

Published:2014-12-01 Issue:23 Volume:57 Page:10044-10057
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Pizzonero Mathieu¹,Dupont Sonia¹,Babel Marielle¹,Beaumont Stéphane¹,Bienvenu Natacha¹,Blanqué Roland¹,Cherel Laëtitia¹,Christophe Thierry²,Crescenzi Benedetta¹,De Lemos Elsa¹,Delerive Philippe¹,Deprez Pierre¹,De Vos Steve²,Djata Fatoumata¹,Fletcher Stephen¹,Kopiejewski Sabrina¹,L’Ebraly Christelle¹,Lefrançois Jean-Michel¹,Lavazais Stéphanie¹,Manioc Murielle¹,Nelles Luc²,Oste Line²,Polancec Denis³,Quénéhen Vanessa¹,Soulas Florilène¹,Triballeau Nicolas¹,van der Aar Ellen M.²,Vandeghinste Nick²,Wakselman Emanuelle¹,Brys Reginald²,Saniere Laurent¹

Affiliation:

1. Galapagos, 102 Avenue Gaston Roussel, 93230 Romainville, France

2. Galapagos, Generaal De Wittelaan L11A3, 2800 Mechelen, Belgium

3. Fidelta, Prilaz Baruna Filipovica 29, 10000 Zagreb, Croatia

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm5012885

Reference24 articles.

1. Glycerolipid Metabolism and Signaling in Health and Disease