Lead Optimization toward Proof-of-Concept Tools for Huntington’s Disease within a 4-(1H-Pyrazol-4-yl)pyrimidine Class of Pan-JNK Inhibitors-Reference-Cited by-同舟云学术

Lead Optimization toward Proof-of-Concept Tools for Huntington’s Disease within a 4-(1H-Pyrazol-4-yl)pyrimidine Class of Pan-JNK Inhibitors

Published:2015-03-19 Issue:7 Volume:58 Page:2967-2987
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Wityak John¹,McGee Kevin F.²,Conlon Michael P.²,Song Ren Hua²,Duffy Bryan C.²,Clayton Brent²,Lynch Michael²,Wang Gwen²,Freeman Emily²,Haber James²,Kitchen Douglas B.²,Manning David D.²,Ismail Jiffry²,Khmelnitsky Yuri²,Michels Peter²,Webster Jeff²,Irigoyen Macarena²,Luche Michele²,Hultman Monica²,Bai Mei²,Kuok IokTeng D.²,Newell Ryan²,Lamers Marieke³,Leonard Philip³,Yates Dawn³,Matthews Kim³,Ongeri Lynette³,Clifton Steve³,Mead Tania³,Deupree Susan⁴,Wheelan Pat⁴,Lyons Kathy⁵,Wilson Claire⁶,Kiselyov Alex¹,Toledo-Sherman Leticia¹,Beconi Maria¹,Muñoz-Sanjuan Ignacio¹,Bard Jonathan¹,Dominguez Celia¹

Affiliation:

1. CHDI Foundation, Inc., 6080 Center Drive, Suite 100, Los Angeles, California 90045, United States

2. Albany Molecular Research Inc. (AMRI), 26 Corporate Circle, Albany, New York 12212-5098, United States,

3. BioFocus Discovery Services, Charles River Laboratories, Chesterford Research Park, Little Chesterford, CB10 1XL, United Kingdom

4. Tandem Laboratories, 2202 Ellis Road, Durham, North Carolina 27703, United States,

5. Pharmacokinetics Consultant to CHDI, P.O. Box 64, Holland, New York 14080, United States,

6. Evotec, 114 Milton Park, Abingdon, OX14 4SA, United Kingdom

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm5013598

Reference46 articles.

1. Targeting JNK3 for the treatment of neurodegenerative disorders

2. Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene

3. Small Molecule c-jun-N-Terminal Kinase Inhibitors Protect Dopaminergic Neurons in a Model of Parkinson’s Disease

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