Variation of the Net Charge, Lipophilicity, and Side Chain Flexibility in Dmt1-DALDA: Effect on Opioid Activity and Biodistribution-Reference-Cited by-同舟云学术

Variation of the Net Charge, Lipophilicity, and Side Chain Flexibility in Dmt1-DALDA: Effect on Opioid Activity and Biodistribution

Published:2012-11-12 Issue:22 Volume:55 Page:9549-9561
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Novoa Alexandre¹,Van Dorpe Sylvia²,Wynendaele Evelien²,Spetea Mariana³,Bracke Nathalie²,Stalmans Sofie²,Betti Cecilia¹,Chung Nga N.⁴,Lemieux Carole⁴,Zuegg Johannes⁵,Cooper Matthew A.⁵,Tourwé Dirk¹,De Spiegeleer Bart²,Schiller Peter W.⁴,Ballet Steven¹

Affiliation:

1. Department of Organic Chemistry, Vrije Universiteit Brussel, Pleinlaan 2, B-1050 Brussels, Belgium

2. Drug Quality and Registration (DruQuaR) Group, Department of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, B-9000 Ghent, Belgium

3. Department of Pharmaceutical Chemistry, Institute of Pharmacy and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innsbruck, Austria

4. Laboratory of Chemical Biology and Peptide Research, Clinical Research Institute of Montreal, Montreal, QC, Canada

5. Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm3008079

Reference50 articles.

1. Antinociceptive interactions of opioid delta receptor agonists with morphine in mice: Supra- and sub-additivity

2. FOUR DIFFERENT TYPES OF OPIOID PEPTIDES WITH MIXED μ AGONIST/δ ANTAGONIST PROPERTIES

3. Pentapeptides Displaying μ Opioid Receptor Agonist and δ Opioid Receptor Partial Agonist/Antagonist Properties

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