A Versatile Intermediate for the Preparation of C-Functionalized Azamacrocycles and Application to the Synthesis of the Potent Anti-HIV Agent (±)JM2936
Author:
Affiliation:
1. Johnson Matthey Pharmaceutical Research, 1401 King Road, West Chester, Pennsylvania 19380 and Johnson Matthey Technology Centre, Blounts Court, Sonning Common, Reading RG4 9NH, U.K.
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/jo951499w
Reference37 articles.
1. Potent and selective inhibition of human immunodeficiency virus (HIV)-1 and HIV-2 replication by a class of bicyclams interacting with a viral uncoating event.
2. Unexpected selectivity in the alkylation of polyazamacrocycles
3. Synthesis and Structure-Activity Relationships of Phenylenebis(methylene)-Linked Bis-Tetraazamacrocycles That Inhibit HIV Replication. Effects of Macrocyclic Ring Size and Substituents on the Aromatic Linker
4. Synthesis and Structure−Activity Relationships of Phenylenebis(methylene)- Linked Bis-tetraazamacrocycles That Inhibit Human Immunodeficiency Virus Replication. 2. Effect of Heteroaromatic Linkers on the Activity of Bicyclams
5. Characterization of 2,2′-bi-(1,4,8,11-tetra-azacyclotetradecane): X-ray structure and properties of the dinuclear complex [Ni2(C20H46N8)][ClO4]4
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