1. Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, Colorado 80206-2761, Department of Chemical Engineering, 2114 Sweeney Hall, Iowa State University, Ames, Iowa 50011-2230, Bioinformatics and Computational Biology Program, 2014 Molecular Biology Building, Iowa State University, Ames, Iowa 50011-3260, and Department of Medicine, University of Colorado Health Sciences Center, 4200 East Ninth Street, Denver, Colorado 80262