Discovery of Azo-Aminopyrimidines as Novel and Potent Chitinase OfChi-h Inhibitors via Structure-Based Virtual Screening and Rational Lead Optimization

Author:

Dong Lili1ORCID,Shen Shengqiang2,Jiang Xi34,Liu Yaxin1,Li Jingjing1,Chen Wei3,Wang Yizhen1,Shi Jiakun1,Liu Jiaxin1,Ma Shujie1,Zhang Lihui1,Dong Jingao1,Yang Qing34ORCID

Affiliation:

1. State Key Laboratory of North China Crop Improvement and Regulation, College of Plant Protection, Hebei Agricultural University, Baoding 071001, China

2. Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100091, China

3. State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China

4. Guangdong Laboratory for Lingnan Modern Agriculture (Shenzhen Branch), Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518120, China

Funder

National Natural Science Foundation of China

Special Funds for Science Technology Innovation and Industrial Development of Shenzhen Dapeng New District

Key Research and Development Project of Hebei Province

Research Project of Basic Scientific Research Business Expenses of Hebei Provincial Universities

Shenzhen Science and Technology Program

State Key Laboratory of North China Crop Improvement and Regulation

Publisher

American Chemical Society (ACS)

Subject

General Agricultural and Biological Sciences,General Chemistry

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