Computation-Guided Rational Design of Cysteine-Less Protein Variants in Engineered hCGL-Reference-Cited by-同舟云学术

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Computation-Guided Rational Design of Cysteine-Less Protein Variants in Engineered hCGL

Published:2024-04-23 Issue:17 Volume:72 Page:9937-9946
ISSN:0021-8561
Container-title:Journal of Agricultural and Food Chemistry
language:en
Short-container-title:J. Agric. Food Chem.

Author:

Zhang Qian¹,Fan Shuai¹,Tang Mengjia²,Wang Chenyu²,Li Xiaoxiao²,Jin Yuanyuan¹,Yang Zhaoyong¹^ORCID

Affiliation:

1. NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China

2. School of Pharmacy, North China University of Science and Technology, Tangshan 063210, Hebei, China

Funder

National Key Research and Development Program of China

Chinese Academy of Medical Sciences

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jafc.3c06821

Reference35 articles.

1. Oncogene-Selective Sensitivity to Synchronous Cell Death following Modulation of the Amino Acid Nutrient Cystine

2. Cysteine Depletion, a Key Action to Challenge Cancer Cells to Ferroptotic Cell Death

3. Dietary modifications for enhanced cancer therapy

4. Systemic depletion of L-cyst(e)ine with cyst(e)inase increases reactive oxygen species and suppresses tumor growth

5. Cysteine depletion targets leukemia stem cells through inhibition of electron transport complex II

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